The polyoxyethylene castor oil Cremophor EL modifies multidrug resistance
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منابع مشابه
Synergistic reversal of multidrug-resistance phenotype in acute myeloid leukemia cells by cyclosporin A and cremophor EL.
Cremophor (Crem) EL, the vehicle for intravenous delivery of cyclosporin A (CsA), has been reported to counteract multidrug resistance (MDR) in P-glycoprotein (Pgp)-over-expressing cell lines. Because of this, we sought to determine whether Crem functions independently as a modulator of MDR in blast cells obtained from acute myelogenous leukemia (AML) patients, and the nature of its interaction...
متن کاملSuspected anaphylactic reaction to Cremophor EL.
There have been several reports of anaphylactoid reactions to the intravenous anaesthetic drugs Althesin (alphaxalone and alphadolone) and propanidid (Epontol).' The culprit in some of these reactions may have been Cremophor EL, a surfactant common to both drug formulations. Cremophor EL is produced by the epoxylation of castor oil and is actually a complex mixture of compounds. We report a cas...
متن کاملThe alteration of plasma lipoproteins by cremophor EL.
Cremophor EL (CRM) is a non-ionic amphipathic emulsifier which has been used as a parenteral vehicle for many hydrophobic drugs. At concentrations above 0.4 mg ml-1, CRM alters lipoproteins so as to reduce their electrophoretic mobility; high density lipoprotein (HDL) is somewhat more sensitive than low density lipoprotein (LDL) in this regard. The same phenomenon was observed with Triton X-100...
متن کاملInfluence of Cremophor El on the bioavailability of intraperitoneal paclitaxel.
It has been hypothesized that the paclitaxel vehicle Cremophor EL (CrEL) is responsible for nonlinear drug disposition by micellar entrapment. To gain further insight into the role of CrEL in taxane pharmacology, we studied the pharmacokinetics of paclitaxel in the presence and absence of CrEL after i.p. and i.v. dosing. Patients received an i.p. tracer dose of [G-(3)H]paclitaxel in ethanol wit...
متن کاملPolyoxyethylene hydrogenated castor oil modulates benzalkonium chloride toxicity: comparison of acute corneal barrier dysfunction induced by travoprost Z and travoprost.
PURPOSE To determine the element that modulates benzalkonium chloride (BAC) toxicity by using a new electrophysiological method to evaluate acute corneal barrier dysfunction induced by travoprost Z with sofZia (Travatan Z(®)), travoprost with 0.015% BAC (Travatan(®)), and its additives. METHODS Corneal transepithelial electrical resistance (TER) was measured in live white Japanese rabbits by ...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1990
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1990.335